Each chewable ProstaBiome tablet contains 500 million colony forming units (CFUs) of multiple probiotic strains. You get Lactobacillus acidophilus, Lactobacillus fermentum, Lactobacillus gasseri, and Lactobacillus rhamnosus, among other strains. These strains have been shown to promote good bacteria in your digestive tract. According to the makers of ProstaBiome, the root cause of prostate problems is in your gut – not your prostate. By targeting bad bacteria in your gut, you can purportedly allow the prostate to repair itself.

Bita sitosterol is a cholesterol-like compound found in plants. It’s best-known in the supplement space for targeting benign prostatic hyperplasia, or BPH. Beta sitosterol has been shown to significantly improve urinary flow and decrease the amount of urine left in the bladder, according to Mount Sinai – although it has not been shown to directly shrink the prostate.

Saw palmetto is found in prostate health supplements, testosterone boosters, and other formulas. As Mount Sinai explains, as palmetto “appears to work like Proscar and Avodart” by preventing testosterone from being converted into dihydrotestosterone (DHT), which is needed for prostate growth. Some studies suggest saw palmetto is as effective as these drugs while providing fewer side effects.

Cinnamon is one of the more unique ingredients in ProstaBiome. Unlike saw palmetto and beta sitosterol, cinnamon is not typically found in prostate health supplements. Nevertheless, some small studies have linked cinnamon to reduced prostate cancer. A 2024 study on rats, for example, found cinnamon had “chemopreventive effect,” using multiple bioactive compounds to prevent prostate carcinogenesis.

ViNitrox is a proprietary nutritional supplement ingredient created by NEXIRA. It’s a combination of apple and grape polyphenols designed specifically to boost endurance and energy. Polyphenols are plant-based antioxidants shown to neutralize free radicals throughout the body that cause inflammation. ViNitrox is specifically designed to boost nitric oxide (NO) production, helping to widen blood vessels and support blood flow. According to NEXIRA, some of the benefits of ViNitrox include reduced oxidative stress, better endurance, and delayed fatigue.

Grape seed extract is packed with resveratrol, a natural antioxidant. Instead of eating mountains of grapes daily, you can take a single serving of ProstaBiome. Resveratrol can neutralize free radicals that cause inflammation. Many men with an enlarged prostate also have inflammation, and controlling this inflammation can help control symptoms.

Kelp is one of several seaweeds found in nutritional supplements and linked to prostate health. Some men take kelp daily for prostate health. Kelp and other seaweeds are loaded with iodine, a crucial mineral involved in hundreds of processes throughout the body. Some believe kelp has anti-tumor effects and helps with prostate cancer, while others take kelp supplements daily to support normal prostate size.